Will Antibiotics Cure Periodontal Disease

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It is important to note that antibiotics should only be prescribed by a licensed dental professional and used judiciously to avoid the development of antibiotic resistance. In addition, antibiotics are ineffective in treating gingivitis, the earliest and mildest form of periodontal disease.

Will Antibiotics Cure Periodontal Disease?

What Is Periodontal Disease?

Gum disease, also known as periodontal disease, is an inflammatory condition that affects the gums and supporting structures of the teeth. It is primarily caused by bacterial plaque that accumulates on the teeth and triggers an inflammatory response in the gums.

Gum disease can lead to tooth loss and other oral health complications if left untreated.

Stages of Gum Disease

Gingivitis: Gingivitis is the early and mild form of gum disease. It occurs when bacterial plaque accumulates on the teeth and causes inflammation of the gums, leading to redness, swelling, and bleeding during brushing or flossing. Gingivitis is reversible with proper oral hygiene and professional dental care.

Periodontitis: If gingivitis is not treated, it can progress to periodontitis. In this stage, the inflammation extends deeper into the supporting structures of the teeth, including the bone and connective tissue. Periodontitis is characterized by the formation of pockets between the gums and teeth (periodontal pockets), bone loss, and eventual dental loss if not treated.

How To Treat Gum Disease

Treating gum disease depends on the stage and severity of the condition. Early intervention, good oral hygiene, and professional dental care are essential to prevent the progression of gum disease and maintain good oral health.


Professional Dental Cleaning

Regular professional cleaning is essential to maintain good oral hygiene and prevent gum disease. During a cleaning, a dental hygienist will remove plaque and tartar buildup from teeth surfaces and around and below the gum line. Professional dental cleaning helps to prevent gingivitis, the earliest stage of gum disease.


Scaling and Root Planing

Scaling and root planing is a non-surgical procedure, also known as deep cleaning, used to treat gum disease. Scaling involves the removal of plaque and tartar from teeth surfaces and below the gum line. Root planing involves smoothing the roots of the teeth to allow the gums to reattach and heal. The procedure is typically used for patients with moderate gum disease.

Flap Surgery

Flap surgery, also known as pocket reduction surgery, is one of the surgical treatments performed by a periodontist (a gum specialist) for advanced cases of gum disease(aggressive periodontitis). During the surgery, the gums are lifted back to expose the tooth roots, allowing for thorough scaling and root planing. The gums are then sutured back into place, reducing the pocket depth around the teeth and making it easier to clean and maintain.

Soft Tissue Grafts

These grafts are used to treat gum recession, a common side effect of severe periodontitis. Soft tissue grafts involve taking a small amount of tissue from the patient’s palate or another donor source and attaching it to the affected area, covering the exposed tooth roots and helping to prevent further gum recession.

Bone Grafts

Bone grafts are used in cases where gum disease has caused significant bone loss around the teeth. The procedure involves placing bone graft material (either from the patient’s own bone, a donor, or synthetic material) in the areas where the bone has been lost, encouraging new bone growth and helping to stabilize the teeth.

Guided Tissue Regeneration

It is a surgical procedure used to promote the regeneration of bone and gum tissue lost due to gum disease. A small piece of biocompatible fabric is placed between the existing bone and the tooth, preventing unwanted tissue from growing into the bone defect and allowing the bone and connective tissue to regenerate.

The Role of Antibiotics In Periodontal Treatment

Antibiotics work by either killing bacteria or inhibiting their growth. They target specific features of bacterial cells, such as their cell walls or protein synthesis, which helps to eliminate or reduce the number of harmful bacteria causing infections.


Topical or oral antibiotics are used as adjunctive therapies in treating periodontal diseases to help eliminate or control the bacterial infections that contribute to gum disease. They can reduce inflammation and support the healing process. The recommended systemic or topical antibiotics are used to reduce bacterial growth, kill bacteria, and target the specific bacterial infection causing gingivitis or periodontitis. In the case of periodontal diseases, they should be used in conjunction with other therapies, such as scaling and root planing or other procedures, to eliminate harmful bacteria and support the healing process, as they cannot resolve periodontal disease on their own.

Antibiotic Treatment

Common Topical or Oral Antibiotics In Treating Gum Disease

There are two main categories of antibiotics used in periodontal treatment: systemic antibiotics and topical antibiotics.

Systemic Antibiotics: These are taken orally or intravenously and work throughout the entire body. They specifically target the bacteria causing periodontal disease systemically, making them suitable for more widespread infections or more severe cases of gum diseases. Systemic antibiotics may also be used in cases where there is a risk of the infection spreading to other parts of the body.

Topical Antibiotics: These are applied directly to the affected area in the mouth, such as in the form of gels, chips, or strips. They help to eliminate disease-causing bacteria locally, with a higher concentration of the medication at the site of infection. Topical antibiotics are generally used for localized treatment and can help control bacterial growth and inflammation in a specific area of the mouth.

Systemic or topical antibiotics are commonly used to treat gum diseases caused by bacterial infections, such as gingivitis and chronic periodontitis. These medications eliminate disease-causing bacteria, reduce inflammation, and prevent the growth of harmful bacteria in the mouth.

Oral antibiotics, such as Tetracycline, Azithromycin, Metronidazole, Amoxicillin, and Clindamycin, are prescribed to kill bacteria and reduce bacterial growth that leads to gum disease.

Tetracycline: This group of medications, which includes tetracycline hydrochloride, doxycycline, and minocycline, serves as the primary drugs used in periodontal treatments. Tetracycline includes antibacterial properties helping to reduce inflammation and blocking collagenase, a protein responsible for destroying connective tissues that anchor teeth in the mouth.

Azithromycin: Azithromycin is an antibiotic that can help fight the bacterial infection causing gingivitis. Azithromycin is often prescribed as part of a treatment plan that includes professional dental cleaning and improved oral hygiene practices. It helps reduce inflammation, swelling, and bleeding associated with the infection, promoting healing and preventing further damage to the gums and supporting structures of the teeth.

Metronidazole: Metronidazole will typically be used with amoxicillin or tetracycline to address chronic oral infections. This type of antibiotic can effectively reduce inflammation and fight bacterial growth in severe periodontitis.

Amoxicillin: Amoxicillin is commonly used to treat bacterial infections in the oral cavity, including gum diseases. Amoxicillin is designed to combat bacteria and bacterial infections throughout the body. Rather than directly killing bacteria, it prevents microbes from forming the walls that encase them, which is crucial for bacterial reproduction and survival. This targeted approach helps patients suffering from various infections by disrupting the growth and spread of harmful bacteria.

Clindamycin: Clindamycin is an effective antibiotic that inhibits the growth of various harmful bacterial infections. By making it difficult for bacteria to thrive and multiply, clindamycin is a valuable treatment option for numerous serious bacterial infections, helping maintain overall health and well-being.

Topical antibiotics, such as Atridox, Periochip, Actisite, Elyzol, and Arestin, are applied directly to the affected area to target oral bacteria and reduce inflammation. They prevent microbes from forming walls, which helps to reduce plaque buildup. The primary advantage of topical antibiotics is the reduced dosage required, as they are applied directly to the infection site.


Atridox®: Atridox® is a topical antimicrobial gel containing doxycycline, a tetracycline family member. It is administered directly into the periodontal pocket, slowly releasing the antibiotic over time, maximizing its effect on the targeted area.


Arestin®: Arestin is an antibiotic that a dentist applies directly into the affected gum pockets after completing a scaling and root planing (SRP) treatment. This minocycline antibiotic is administered to the gums as tiny capsules.


PerioChip®: PerioChip® is a chip placed into gum pockets following root planing procedures. It releases Chlorhexidine, an antibacterial antiseptic, to help reduce pocket depth in most forms of periodontal diseases. 


Elyzol®: Elyzol is a type of antibiotic in the form of gel and strip that is effective in treating certain types of bacterial infections. When applied to the affected areas in the mouth, Elyzol® helps reduce inflammation and the number of harmful bacteria, which can alleviate the symptoms of gum diseases and promote healing.

Actisite®: Actisite is a thin strip like a dental floss containing tetracycline hydrochloride your dentist will place between your tooth and infected gum tissue to fight bacteria and pocket depths.


Both systemic or topical antibiotics can be used with other procedures or therapies to provide the most effective treatment for patients suffering from gum diseases. Dentists may recommend systemic antibiotics for serious bacterial infections, while topical antibiotics are often prescribed as a complementary treatment alongside other therapies, such as deep cleaning.